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July 5, 1965

Atherosclerosis Affected by Laws of Fluid Mechanics

JAMA. 1965;193(1):A39-A42. doi:10.1001/jama.1965.03090010099047

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The various forces involved in the circulation of the blood-vascular hemodynamics—play a major role in the pathogenesis of atherosclerosis, a New York University Medical Center investigator says.

"Recent studies in humans and animals and experiments with circulatory models support the concept that fluid mechanics are the primary factor in the etiology, localization, and progressive pathology of atherosclerosis," Meyer Texon, MD, told The Journal.

A study of the factors determining blood velocity may yield data useful in controlling vascular dynamics and the intimal response to hydraulic forces, he added.

Texon and three coworkers, Milton Helpern, MD, chief medical examiner for New York City; Anthony M. Imparato, MD, and Richard Skalak, reported their studies in vascular dynamics in a paper and scientific exhibit at the Annual Convention of The American Medical Association.

These investigators reported that autopsy findings and data from hemodynamically induced arterial lesions in dogs indicate that the minute thickening

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