Nephropathy developed in a 33-year-old woman following the ingestion of deteriorated tetracyclines, manifested by severe acidosis, massive proteinuria, renal glucosuria, aminoaciduria, hypokalemia, hypouricemia, decreased phosphorus reabsorption, Bence-Jones proteinuria, transient hyperglycemia, and a maculopapular rash. There was a complete recovery in 25 days. A renal biopsy revealed severe tubular changes. It is suggested that the glomeruli are also affected, but to a lesser degree, and participate in the creation of the massive proteinuria.
Mavromatis F. Tetracycline Nephropathy: Case Report With Renal Biopsy. JAMA. 1965;193(3):191–194. doi:10.1001/jama.1965.03090030013003
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