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July 19, 1965

Wegener's Granulomatosis and Corneo-Scleral Ulcer

JAMA. 1965;193(3):248-249. doi:10.1001/jama.1965.03090030070032

To the Editor:—  Wegener's granulomatosis is a rare collagen disease of unknown etiology originally described by Klinge.1 Wegener2 was the first to correlate the findings into a specific entity distinct from periartertis nodosa. Since then little has been added to basic knowledge of the etiology or pathogenesis of this disease.The usual clinical picture has been well outlined by Fahey.3 There is no predisposition for either sex. Age varies greatly, but is usually in the third to fifth decade. The onset is heralded by upper-respiratory-tract symptoms, most often nasal stuffiness and sinusitis. Abnormal pulmonary findings, fever, and weight loss follow, and the course progresses unfavorably, ending with renal failure as a rule. McDonald4 characterizes the three salient findings as a necrotizing granulomatous process of the respiratory tract, a generalized vasculitis of the arteries and veins, and focal glomerulitis.5To our knowledge only five previous documented