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July 26, 1965

Chemical Carcinogenesis and Cancers

JAMA. 1965;193(4):324. doi:10.1001/jama.1965.03090040068031

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This impressive treatise reflects, to a large extent, the lifetime experience of the senior author and may be considered a companion piece to his earlier monograph Occupational Tumors and Allied Diseases (1942). The present book deals not only with cancers occurring in high-risk occupations, but with the total carcinogenic environment surrounding modern man. The text expounds the physicochemical properties of the important classes of organic and inorganic carcinogens, and critically analyzes their mechanisms, their relationship to mutagens and teratogens, and factors modifying carcinogenesis. In the presentation of methods for bioassay of carcinogens, the insidious effects of small doses acting over prolonged periods of time are documented, and attention is called to the fact that few carcinogens have an effective attack rate of 100%. Discussing the serious difficulties in performance and interpretation of carcinogen assays, the authors propose specific approaches in order to deal effectively with the man-made "pathogenic chemical jungle"

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