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August 16, 1965

Pulmonary Clearance of Radio-Iodinated Serum Albumin I 131

Author Affiliations

From the Medical Service (Dr. Ramirez-R.) and Biochemistry Research Laboratory (Mr. Buddemeyer) Veterans Administration Hospital and the departments of medicine, University of Maryland School of Medicine and the Johns Hopkins University School of Medicine (Dr. Ramirez-R.) Baltimore.

JAMA. 1965;193(7):595. doi:10.1001/jama.1965.03090070045014

Marked delay in the clearance of radio-iodinated serum albumin I131 (Risa) when administered intravenously was recently observed in one patient with alveolar proteinosis and in another with uremic pneumonitis.1 In the same study, a moderate delay in the rate of pulmonary clearance of intravenous radio-iodinated serum albumin was noted in subjects in congestive heart failure. Since this technique for measuring pulmonary clearance could have wide applicability, an exploration of its diagnostic and prognostic potentialities was undertaken. This paper presents the negative results of this exploration in tuberculosis, alveolar proteinosis, and other pulmonary disorders.

Material and Methods.—  The right lung of 28 subjects was studied. Their diagnoses, as established bacteriologically or histologically, are listed in Table 1. Six of the 18 patients with tuberculosis had no involvement of the right lung and these uninvolved lungs and the right lungs of two normal subjects were used as "control lungs." The