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To the Editor:—
Drs. Koplowitz et al, reporting on "The Radioisotope Renogram" (JAMA192:1032-1034 [June 21] 1965), applied our normal values to their renograms (JAMA180:454-459 [May 5] 1962). Their technique of renography differed from ours and the use of our normal values in their renogams is accordingly invalid. The significant difference in technique seems to have been that our normal values were obtained with the patient supine, after 12 hours of dehydration, whereas Dr. Koplowitz's patients were hydrated and studied in the sitting position. Brown et al (JAMA186:211-214 [Oct 19] 1963) defined normal values for hydrated patients in the sitting position. The differences between their normal values and ours were striking. In applying their normal values to their own patients Brown found, as we had, that the quantitative interpretation of the renogram gave much greater diagnostic accuracy.
Stewart BH, Haynie TP. Radioisotope Renograms. JAMA. 1965;193(9):744–745. doi:10.1001/jama.1965.03090090050023
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