For several years, chlorpropamide has been an oral hypoglycemia drug used frequently in our private practice program of diabetic management. The cases of 147 patients known to have taken this agent for more than 18 months were reevaluated. Of the 147, a total of 122 had successful diabetic control for 24 to 63 months of drug dependent management, or were in satisfactory control by means of diet alone. Twenty-one of the 25 late failures were due to intercurrent stress or failure to adhere to the prescribed nutritional patterns. Three late failures in cooperative patients appeared due to secondary drug failure. Infection, myocardial infarction, and other stresses necessitated temporary insulin therapy in 20 cases, but after termination of stress, control was reestablished with diet and chlorpropamide.
Benner EJ, Partridge JW, Holcomb B. An Evaluation of Long-Term Chlorpropamide Therapy. JAMA. 1965;193(10):763–766. doi:10.1001/jama.1965.03090100009002
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