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The "old days" of anatomic and morphologic pathology are surely over, for this is the age of molecular biology. Such great morphologists as Virchow, Rokitansky, and those who followed contributed extensively to our knowledge of disease of the morphologic understanding of cancer and its metastases, of myocardial infarction and its relation to coronary blood flow, of peptic ulcer and the complications of perforation and hemorrhage, of the varieties of cirrhosis, and the classification of the leukemias and lymphomas. Much of our understanding of phenomona such as inflammation and necrosis is the result of long, careful, intelligent observation deriving mostly from the autopsy table. Undoubtedly, refinement in microscopy, especially of the electron microscope, will bring a better understanding of subcellular particles and ultra-structure, but in spite of all the knowledge that gross and microscopic pathology has taught us in the past, today search for the causes of disease is devoted to
Davidson CS. The Autopsy in the Age of Molecular Biology. JAMA. 1965;193(10):813–814. doi:10.1001/jama.1965.03090100059016
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