Although radiation therapy is generally considered the procedure of choice in treating invasive carcinoma of limited extent, the renaissance of radical surgical procedures in experienced hands has yielded high cure rates. Rather than regard these procedures as competitive, an effort is being made in a number of centers to use the surgical and radiotherapeutic modes in a complimentary fashion and to thereby provide a treatment specifically suited to each patient. To this end, a number of tests are being developed to predict the radiosensitivity and radiocurability of an individual case prior to or during irradiation, so that surgical intervention may permit successful salvage of a cancer likely to persist or recur because of radioresistance.
One of the commonly stated concepts is that anaplastic tumors are radiosensitive and well-differentiated carcinomas are radioresistant. Although support for this view can be found in Martzloff's1 and Novak's2 studies, which suggest that differentiated
Rubin P. Cancer of the Cervix Stage II. JAMA. 1965;193(10):822. doi:10.1001/jama.1965.03090100068020
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