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September 6, 1965

Acute Plasmocytic Leukemia Responsive to Cyclophosphamide

JAMA. 1965;193(10):844-847. doi:10.1001/jama.1965.03090100090039

A CASE OF acute plasmocytic leukemia is presented because of its rarity and because of its significant subjective and objective response to cyclophosphamide (Cytoxan). In the related disease, plasmocytic myeloma,1-8 where the therapeutic effect is more difficult to measure, many therapeutic agents have been tried, including cyclophosphamide.9,10 The striking response of this patient's disease to cyclephosphamide supports the observations reported in patients with plasmocytic myeloma.

Report of a Case  A 54-year-old woman was admitted to the Multnomah County Hospital, Portland, Ore, on Dec 5, 1963, because of back pain. She had been well until October when she began having pain in the lumbosacral spine. This progressed to involve the thoracic and cervical spine, and was accompanied by gradually increasing weakness and malaise until, on Nov 19, she could no longer continue her work as a cleaning woman. Chills, fever, night sweats, and decreased urine output, with an urge

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