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September 6, 1965

Strongyloidiasis Treated With Pyrvinium Pamoate

JAMA. 1965;193(10):847-848. doi:10.1001/jama.1965.03090100093040

PYRVINIUM chloride (Vanquin) suspension was used by Brown and Sterman in 1958 as a treatment for Strongyloides stercoralis infection in man with encouraging results.1 Production of this compound was later discontinued by the manufacturer in favor of pyrvinium pamoate (Povan) which like the chloride, is effective against oxyuriasis, usually requires only a single dose, and is better tolerated in the gastrointestinal tract.2 A trial of pyrvinium pamoate for the treatment of strongyloidiasis was prompted by the paucity of reports of such use,3,4 by the unavailability of pyrvinium chloride, and by the disturbing toxicity of dithiazanine,5 although the latter is highly efficacious against Strongyloides infection.6

Methods  Twenty-four patients with S stercoralis infection were selected at random in the Tropical Disease Clinic at Bushwick Health Center, New York. S stercoralis infection is the fifth most common helminthiasis found in such clinics.7 The presence of the infection

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