High-molecular-weight dextran and millipore filtration have been successfully utilized for isolation of cancer cells and large hematopoietic elements from blood. Circulating tumor cells were detected in peripheral blood from nine (3.5%) of 255 patients. Regional blood samples were positive for tumor cells in two of 35 cases. Two of 28 patients having local blood examined were found to have tumor cells. A majority of the patients (11 of 13 cases) with detectable tumor cells in the blood had disseminated cancer. No tumor type predominated in yielding circulating cancer cells. The application of current criteria in the diagnosis of circulating tumor cells indicates that their presence is substantially less than previously reported. Immature hematopoietic elements, which require differentiation from malignant cells, are commonly found in the blood of patients with carcinoma.
Romsdahl MM, Valaitis J, McGrath RG, McGrew EA. Circulating Tumor Cells in Patients With Carcinoma: Method and Recent Studies. JAMA. 1965;193(13):1087–1090. doi:10.1001/jama.1965.03090130015003
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