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October 4, 1965

Perfusion With Diluted Blood in Treatment of Congenital Heart Disease

JAMA. 1965;194(1):19-22. doi:10.1001/jama.1965.03090140027006

Since May 1962, hemodilution has been routinely employed for cardiopulmonary bypass at the Colorado General Hospital. The clinical results of these techniques, as applied to 95 patients with congenital heart disease, show that 83 of these patients survived the operative procedure. Priming of a disposable bubble-oxygenator was accomplished with 5% dextrose and 0.11% saline or a mixture of this diluent in homologous blood. Postoperative complications among the survivors were late postoperative anemia, hyponatremia, and unexplained fever. These complications were frequent, but rarely serious. Blood replacement during the operative procedure averaged 20.9 ml/kg per patient. Postoperative blood loss averaged 10.1 ml/kg per patient. It is concluded from this experience that, at this institution, hemodilution offers a safe technique for cardiopulmonary bypass in patients with congenital heart disease.