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October 4, 1965

Ventricular Localization of Bound Gamma Globulin in Idiopathic Disease of the Myocardium

JAMA. 1965;194(1):59-61. doi:10.1001/jama.1965.03090140067017

Idiopathic disease of the myocardium (IDM) is a disorder of obscure origin. While the clinical and pathological features of this syndrome have been well characterized,1-3 the underlying mechanism is unknown. Further confusion has arisen from the variety of synonyms employed in describing it: (1) chronic pernicious myocarditis, (2) idiopathic cardiomegaly, (3) adult fibroelastosis, (4) obscure cardiopathy, (5) primary myocardial disease, (6) noncoronary cardiomyopathies, (7) endocardial fibrosis, (8) heart disease of unknown etiology, (9) cardiac hypertrophy of unknown etiology, and (10) idiopathic myocardial hypertrophy. Because of the striking clinical and histological similarities between this entity and chronic infectious myocarditis, this study of IDM on an infectious-immune basis was made.

Materials and Methods  Tissue for this study was obtained either by biopsy or autopsy from nine patients meeting rigid predetermined criteria for inclusion in a clinical study of IDM.3 Control materials were obtained from 16 consecutive autopsies. Of these control

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