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October 4, 1965

Poststreptococcal Glomerulonephritis: A Ten-Year Follow-Up of an Epidemic

Author Affiliations

From the Minnesota Department of Health, Minneapolis (Drs. Perlman and Kleinman), and the Department of Pediatrics, University of Minnesota, Minneapolis (Drs. Herdman and Vernier). Dr. Vernier is now with the School of Medicine, University of California, Los Angeles.

JAMA. 1965;194(1):63-70. doi:10.1001/jama.1965.03090140071019

Despite many reports regarding the apparent benign prognosis of acute poststreptococcal glomerulonephritis in children,1-4 there remains some question about the relationship of this disease to chronic nephritis.5-9 While many observers have concluded that the two diseases represent distinct and often unrelated entities, recent evidence, primarily from renal biopsies in adults, indicates that certain cases of chronic glomerulonephritis are the results of acute poststreptococcal disease which has failed to heal.9-11 Many previous studies have been deficient because of inadequate follow-up, poor sampling, and the inclusion of diseases that were not clearly acute poststreptococcal glomerulonephritis.

Because of these inadequacies, particularly with regard to precise definition of etiology of the acute disease, we observed a large group of children who had been clearly afflicted with acute poststreptococcal glomerulonephritis in 1953. One-hundred percent (61) of the surviving persons involved in a well-defined epidemic of streptococcal infection with a nephritogenic strain (Redlake

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