Vincristine sulfate and cyclophosphamide were administered concurrently to nine consecutive children with unresectable neuroblastomas. Objective tumor regression was observed in all nine children and complete remission was obtained in seven. The findings of this study indicate that the concurrent use of vincristine sulfate and cyclophosphamide can produce prolonged, symptom-free survival of some children with neuroblastomas. The findings also indicate that some unresectable neuroblastomas will respond to chemotherapy alone or chemotherapy followed by radiation therapy to an extent that allows complete surgical excision.
James DH, Hustu O, Wrenn EL, Pinkel D. Combination Chemotherapy of Childhood Neuroblastoma. JAMA. 1965;194(2):123–126. doi:10.1001/jama.1965.03090150015003
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