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October 25, 1965

Effect of Iopanoic Acid on the Sulfobromophthalein Test

JAMA. 1965;194(4):343-344. doi:10.1001/jama.1965.03090170021007

Twenty-two of 24 healthy subjects showed an elevation of sulfobromophthalein (BSP) levels following ingestion of iopanoic acid (Telepaque); six of the readings were abnormal. Our data suggest that there is competition for excretion of iopanoic acid and BSP, which results in false elevation of BSP readings. To avoid errors in the diagnosis of liver disease, it is recommended that the BSP test and cholecystography not be performed concomitantly.