To the Editor:—
The Ornade Spansule (chlorpheniramine maleate, 8 mg; phenylpropanolamine hydrochloride, 50 mg; and isopropamide iodide, 2.5 mg), a widely-used orally administered antihistaminic-decongestant, has been reported to cause fever, thirst, drowsiness, tachycardia, "nervousness," insomnia, blurred vision, photophobia, dysphagia, disorientation, and increased menstrual flow.1 It has not been generally known to cause hypertension in a previously normotensive individual.A 20-year-old oriental man was brought to the emergency room complaining of a severe bilateral occipital headache on both sides of 20 minutes' duration. He was in a moderately disoriented, agitated state and was rolling about the bed, holding his head. On physical examination his blood pressure was 220/120 mm Hg, pulse rate, 110 beats per minute, temperature 96 F (35.6 C). His pupils were slightly dilated but equal and reacted to light; he had marked photophobia. Funduscopic examination resulted in normal findings. There was marked spasm of the paravertebral musculature
Ostern S, Dodson WH. Hypertension Following Ornade Ingestion. JAMA. 1965;194(4):472. doi:10.1001/jama.1965.03090170150037
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