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Two separate studies—in Texas and Maryland—have found γ-globulin ineffective as a prophylaxis against serum hepatitis.
Although dosage schedules varied, neither investigation supported the value of the antibody-rich plasma protein. Both were reported to the American Association of Blood Banks meeting in Miami Beach. Both focused on mass transfused patients.
In the Texas group, the occurrence of serum hepatitis among 1,703 patients who received γ-globulin was not significantly less than among 3,310 patients who did not.
The Maryland study encountered more cases in the treated group than among controls.
Open Heart Surgery
Patients undergoing open heart surgery at the National Institutes of Health Clinical Center, in Bethesda, Md, were studied by Paul J. Schmidt, MD, chief of the blood bank, and colleagues.Previous experience had shown a 12% incidence of hepatitis with jaundice among such patients, who received an average of 25 units of blood each.Eighty-four of the
Gamma-Globulin 'Ineffective' Against Hepatitis. JAMA. 1965;194(4):31. doi:10.1001/jama.1965.03090170167053
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