Congenital agammaglobulinemia occurred in two sibling infants. The syndrome was characterized by rudimentary thymic tissue, generalized lymphoid hypoplasia, and an unremitting course complicated by respiratory and other infections, disseminated moniliasis, and death. Evidences of immunologic deficits were found in four other family members.
Delta BG, Rothenberg AM, Ainsworth HD, Innella F. Congenital Alymphoplasmacytic Agammaglobulinemia With Thymic Dysplasia. JAMA. 1965;194(5):507–511. doi:10.1001/jama.1965.03090180031006
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