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November 1, 1965

Congenital Alymphoplasmacytic Agammaglobulinemia With Thymic Dysplasia

Author Affiliations


From pediatric and laboratory services, Walson Army Hospital, Fort Dix, NJ (Maj Delta, Capt Rothenberg, and Capt Ainsworth); and the First US Army Medical Laboratory New York (Mrs. Innella). Dr. Delta is now at Milwaukee Children's Hospital.

JAMA. 1965;194(5):507-511. doi:10.1001/jama.1965.03090180031006

Congenital agammaglobulinemia occurred in two sibling infants. The syndrome was characterized by rudimentary thymic tissue, generalized lymphoid hypoplasia, and an unremitting course complicated by respiratory and other infections, disseminated moniliasis, and death. Evidences of immunologic deficits were found in four other family members.