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November 1, 1965

Chromosome Studies in Patients With Diabetes Mellitus

JAMA. 1965;194(5):551. doi:10.1001/jama.1965.03090180075018

It is well recognized that the predisposition to diabetes mellitus is genetically determined. The familial incidence of this disease was reported first in 1696 by Morton who observed four children of one family becoming diabetic at the age of dentition. The familial occurrence may be explained by assuming that susceptibility to diabetes is due to homozygosity for a recessive gene.1 The genetic liability to this disease among children born to parents, both of whom are diabetic, is said to be 100%.2 It is also known that there is a significantly higher incidence of spontaneous abortion, stillbirth, premature birth, and congenital anomalies in the offspring of the diabetic parents. Forbes and Engel reported recently on the high incidence of diabetes mellitus in patients with gonadal dysgenesis (Turner's syndrome) and in their close relatives.3 The frequent association between chromosomal anomalies and abortuses, stillborn infants, and patients with gonadal dysgenesis

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