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November 1, 1965

A Nearly Fatal Reaction to Deprol

Author Affiliations

Westhampton Beach. NY

JAMA. 1965;194(5):569-570. doi:10.1001/jama.1965.03090180093032

To the Editor:—  The manufacturers of Deprol (meprobamate and benactyzine hydrochloride) do not mention fatalities, but note that effects from either component might occur after administration. Deprol is widely used for treatment of endogenous depressions. A case of a 23-year-old white woman, who had had depressive episodes for many years was observed. When she was 16 years old she had received a series of 19 shock treatments. Five months ago she participated in group psychotherapy. She had been drinking excessively, and continued to do so after marital separation, but when seen in consultation was advised to discontinue alcohol. She abstained for ten days, after which she persuaded her mother to allow her to have an ounce or two of whiskey about 8:30 PM. About midnight her mother heard a fall and found her daughter on the floor in what she concluded was a drunken stupor. She could not be aroused,