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November 8, 1965

Respiratory Failure in Polyradiculoneuritis Associated With Infectious Mononucleosis

JAMA. 1965;194(6):609-611. doi:10.1001/jama.1965.03090190031008

In a case of Guillain-Barré syndrome associated with infectious mononucleosis, the initial neurological manifestation was mild facial diplegia. However, motor failure, which progressed rapidly despite steroid administration, resulted in respiratory insufficiency. Ventilatory assistance was required to permit survival, which was followed by complete recovery. Early respiratory evaluation, close observation (including serial measurement of appropriate pulmonary factors), and individualized expert respiratory management are important. Such management should decrease substantially the high mortality from respiratory failure in patients with polyradiculoneuritis and should permit the complete recovery that is possible because the neuropathological lesion is usually reversible.