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November 8, 1965

Fibrinolysin: Adjunct to Embolectomy

JAMA. 1965;194(6):35-42. doi:10.1001/jama.1965.03090190129058

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Experimental evidence indicates that retrograde instillation of fibrinolysin into the pulmonary veins implements removal of impacted emboli from the pulmonary artery.

Moreover, this procedure has been used in a clinical embolectomy with excellent results, Thomas Gahagan, MD, told the seventh Congress of the International Cardiovascular Society, Philadelphia.

Some investigators have concluded that prophylactic pulmonary embolectomy is not indicated where there is no immediate threat to life, Dr. Gahagan said, since the spontaneous lysis of thromboemboli has been well demonstrated experimentally and documented clinically.

Dr. Gahagan and his co-workers, Albert Manzor, MD, A. N. Mathur, MD, and Carlos Grodsinsky, MD, have observed, however, that even in dogs, which are reputed to have potent circulating fibrinolysins, pulmonary emboli do not always spontaneously dissolve. On the other hand, surgical removal of all of the embolic material may be difficult, and partial removal may be inadequate.

Dr. Gahagan and his group at Henry Ford

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