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November 15, 1965

Of Mice and Medicine

Author Affiliations

Bloomington, Hawaii

JAMA. 1965;194(7):832-833. doi:10.1001/jama.1965.03090200140037

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To the Editor:—  Have you considered the gift of the mouse to medicine? Do your readers know that 80% of all experimental animals are mice? This creature is our own little Mus musculus, the worldwide house mouse, who was a field mouse before we built houses.Millions of mice are produced annually by breeders in mouse factories. Their lives are spent in glass jars or in boxes of wood, plastic, stainless steel, or galvanized iron, filled with wood shavings or disintegrated corncobs. They eat a carefully vitamin-fortified standard diet or "chow." If a mouse escapes and must forage for himself, he starves, not knowing he is omnivorous. The only fresh food he gets is by cannibalization.Despite his limited 1-cc blood volume, scarcely withdrawn leaving the little fellow intact, and limiting the amount that can be injected through the tail vein, the mouse when young has a flexible skull, making

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