An abundant literature indicates that diverse L clinical conditions and therapy are associated with hypertrophy, or atrophy of the adrenal gland. Weights of uncertain accuracy or a subjective evaluation of a few microscopical preparations, or both, are usually given. Measurements of the gland or its various zones are mentioned in only a few instances. However, conclusions drawn from changes measured in the focal plane of a microscope are inadequate or even misleading. Nichols and Hennigar,1 converting thickness to mass in a derived sphere, demonstrated, in dogs with pulmonary hypertension, that a 9% increase in peripheral radius of the gland results in a 96% increase in mass of zona glomerulosa, a relationship not obvious in the plane of a microscopical field. This communication will show that the zona glomerulosa has a mass disproportionately larger than indicated by linear measurements and that increases in zona fasciculata, without change in thickness of
Nichols J. Adrenal Cortex in Tumors and Hypertension. JAMA. 1965;194(8):893–898. doi:10.1001/jama.1965.03090210057015
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