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November 22, 1965

Hepatoma Metastasizing to the Esophagus

JAMA. 1965;194(8):910-912. doi:10.1001/jama.1965.03090210074027

CARCINOMA metastasizing to the esophagus is rare. Gross and Freedman1 cited a review of 1,000 autopsies performed on patients with cancer in which only 11 esophageal metastases were found. They added one case with primary site in the prostate and refer to three other cases, found in the literature, with distant primaries. Toreson2 found 26 esophageal metastases in 599 consecutive autopsies of patients with cancer. Metastases from distant primary sites were infrequent, occurring in only two of the 11 cases in the series cited by Gross and Freedman, in their own case, and in the three cases they found in the literature, and in only seven of the 26 cases of Toreson. The majority of the cases of esophageal involvement by tumor were from adjacent organs such as stomach, larynx, trachea, or bronchus, presumably by direct extension. Additional reports of malignant neoplasms metastasizing to the esophagus were made

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