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November 22, 1965

Immunofluorescence Studies in a Case of Goodpasture's Syndrome

JAMA. 1965;194(8):914-916. doi:10.1001/jama.1965.03090210078029

THE ASSOCIATION of glomerulonephritis and hemorrhagic pneumonitis was first described by Goodpasture1 in 1919, but only in the past ten years has serious consideration been given to the idea that this represents a distinct clinical and pathologic entity. During this time, nearly 100 cases have been reported and recently reviewed.2 Although the etiology is not known, the recent demonstration of γ-globulin localization in glomeruli has suggested that, as in glomerulonephritis, an immunologic mechanism is responsible for the renal lesion.3

The present report confirms the finding of γ-globulin localization in the glomerular basement membrane and shows for the first time localization of γ-globulin in the alveolar septa. This suggests that the renal and pulmonary lesions are caused by the same mechanism.

Report of a Case  A 17-year-old white boy had scarlet fever at the age of 13, but the disease apparently was not complicated and recovery was uneventful.

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