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November 22, 1965

Vascular Infarction in Small-Bowel Ulcers

Author Affiliations

Los Angeles, Calif

JAMA. 1965;194(8):934-935. doi:10.1001/jama.1965.03090210098038

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To the Editor:—  The two papers on "Potassium-Induced Lesions of the Small Bowel" by Boley, Allen et al (193:997,1965) favor venous infarction as the important factor in the pathogenesis of these ulcerations.In our clinical material, which constitutes one of the largest groups of cases in the country, our pathologists have been unable to demonstrate significant vascular lesions. Noteworthy has been the complete absence of venous thrombotic changes in any of the 30 cases studied.Similarly, in our experimental material, we have not been able to substantiate the existence of primary vascular lesions, either arterial or venous, in conjunction with experimentally produced ulcers. We have recently studied the evolution of the experimental lesion under the operating microscope and have documented by cinematography the absence of change in both arteries and veins supplying the area undergoing damage by topically applied potassium compounds.We cannot, on the basis of studies similar

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