Hepatic ischemia produces many physiological: alterations, and death occurs if occlusion of the vascular inflow is prolonged. The period of occlusion which may be tolerated in dogs is increased by decompression of the portal venous system to prevent venous congestion of the intestinal tract. Jolly and Foster1 reported uniform survival when occlusion was maintained for less than 49 minutes if portal venous decompression was accomplished, while Raffucci and Wangensteen2 obtained uniform survival without portal decompression only if occlusion was less than 20 minutes. One of the problems which has been the subject of study is the development of shock at the time of release of clamps occluding the vessels. In fact, it has been ascertained that animals survive longer when complete occlusion of the hepatic vascular inflow is maintained than when a period of occlusion is followed by release of the clamps. The shock which develops may be
Backlund WM, Stevens TJ, Hamit HF, Jordan GL. Hepatic Ischemia in Dogs. JAMA. 1965;194(10):1116–1118. doi:10.1001/jama.1965.03090230084021
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