This essay is shoptalk concerned with the craft of medical research; it is a credo of creativeness. A century ago Claude Bernard described his approach to science wherein experimental medicine was conceived to be a specific discipline defined as the application of physiology to pathology: "Physiology must be constantly applied to medicine."1 Claude Bernard's classic work has had a continuing and profound influence on successive generations of investigators, but Emerson said, "Each age, it is found, must write its own books; or rather, each generation for the next succeeding."2
It is a pleasant vocation to do experiments while teaching young people how to find out new and beautiful and helpful things—how to do elegant Science. It becomes a philosophy because excellence in work engenders excellence in life. These remarks can be reminiscent of the traditional professor of economics who, it is alleged, knows everything about money but doesn't
Huggins CB. The Business of Discovery in the Medical Sciences. JAMA. 1965;194(11):1211–1215. doi:10.1001/jama.1965.03090240045012
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