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December 13, 1965

Spleen-Function Study With 1-Mercuri-2-Hydroxypropane Labeled With Mercury 197

Author Affiliations

From the departments of radiology and medicine, University of Pittsburgh School of Medicine, Presbyterian-University Hospital, Pittsburgh.

JAMA. 1965;194(11):1254-1256. doi:10.1001/jama.1965.03090240088034

A NEW COMPOUND, 1-mercuri-2-hydroxypropane (MHP) labeled with radioactive mercury (197Hg), for spleen scanning has been introduced by Wagner's group.1 This isotopic preparation offers several advantages in being less time-consuming and having less radiation dose over the previous technique using erythrocytes tagged with sodium chromate Cr 51.2,3 Radioactive-MHP-tagged erythrocytes reach peak activity in the spleen one to three hours after injection. This activity begins to fall fairly rapidly by four to six hours after injection. As a result, the functional state of the spleen or the degree of erythrocytic sequestration can be evaluated at the same time that the scan is done. For spleen scanning, the procedure using radioactive-MHP is much easier to do than the sodium chromate Cr 51-tagged erythrocyte procedure which required heating the erythrocytes for an hour. Using the radioactive-MHP procedure, the erythrocytic sequestration study can be accomplished in three to four hours, while it