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December 20, 1965

Acute Hemolytic Anemia Complicating Infectious Mononucleosis

Author Affiliations

From the departments of internal medicine (Dr. Fekete) and general practice (Dr. Kerpelman), Norfolk General Hospital, Norfolk, Va.

JAMA. 1965;194(12):1326-1327. doi:10.1001/jama.1965.03090250060025

INFECTIOUS mononucleosis is a frequent cause for hospitalization. The usual clinical course of the disease is one of gradual and uneventful recovery. The entity can have such protean manifestations, however, that in the absence of the more classical findings, it may not be suspected. Though unusual, an acute hemolytic anemia can complicate the picture.10 Such a situation can present a very serious medical problem. While approximately only 30 cases have been reported in the American literature, it is conceivable that more would be found if sought for (James, G.W., personal communication, June 6, 1964). In a thorough review of the records at the two major local hospitals, only three cases of this entity were noted in the past five years. The case presented here is one of an infectious mononucleosis complicated by a severe hemolysis which was considered attributable to an autoimmune mechanism.

Report of a Case  A 22-year-old white