The diuretic response to a single intravenous injection of ethacrynic acid was observed on 61 occasions in 31 edematous subjects. Maximal water, sodium, chloride, and potassium diuresis occurred within the first hour, and potassium diuresis continued into the following day. The average urine volume was 1,164 cc over the first three hours and 2,378 cc over 24 hours. Average urinary electrolyte losses for the first three hours were sodium, 114 mEq; chloride, 128 mEq; potassium, 25 mEq. For the subsequent 21 hours they were sodium, 49 mEq; chloride, 44 mEq; and potassium 43 mEq. No significant electrolyte alterations occurred after a single intravenous injection. An effective diuresis was achieved in spite of azotemia, hypochloremia, hyponatremia, and hypokalemia. The drug was particularly effective when administered to eight patients manifesting pulmonary edema on 12 occasions. No significant side effects were encountered.
Irons GV, Kong Y, Ginn WM, Orgain ES. Clinical Experience With Intravenous Administration of Ethacrynic Acid. JAMA. 1965;194(13):1348–1351. doi:10.1001/jama.1965.03090260008002
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