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December 27, 1965

Human Genetics and Its Foundations

Author Affiliations

Ann Arbor, Mich

JAMA. 1965;194(13):1393. doi:10.1001/jama.1965.03090260053026

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This book gives a lucid account of the elementary principles of human genetics. It seems to have been intended primarily as a textbook for an undergraduate course whose students have had no previous genetics. I am not sure I would recommend it to another physician. For one thing the book is very long, and presupposes little knowledge of biology. For another the paragraphs covering the clinical expression of an abnormal genotype (or karyotype) are very brief, and sometimes not quite correct—for example (p 18) it is wrong to summarize Turner's syndrome by saying that the patients are immature females.

Through no fault of the author's, certain parts of the book are already out of date. There is no discussion of somatic hybridization in cultures of mammalian cells, and the more recent (and far more conclusive) experiments on the Lyon hypothesis are not included.

I should think this might be a

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