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December 27, 1965

Rare Isotope May Have Bone Scan Advantages

JAMA. 1965;194(13):33-34. doi:10.1001/jama.1965.03090260075038

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Arare metal isotope with apparently significant advantages in bone scanning is in early clinical use at the Oak Ridge Institute of Nuclear Studies.

Gallium 68 also exhibits potential as a kidney scan preparation, according to Raymond L. Hayes, PhD.

Animal and clinical results with the isotope were outlined by the ORINS senior scientist at a recent symposium on radioactive pharmaceuticals at Oak Ridge.

Clinical advantages of68Ga, Dr. Hayes said, include:

  • A short "half-life" of 1.13 hours and rapid tissue clearance, which enables quick repetition of such tests with less patient exposure to radioactivity;

  • A rapid and apparently preferential localization in bone, kidney, and urinary bladder;

  • Decay primarily by positron emission with a relatively small amount of the more dangerous gamma rays;

  • Feasibility of obtaining 68Ga from a compact, less expensive generator instead of a cyclotron or other types of accelerators.

Some clinicians already are

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