The effect of fluid therapy on shock mortality and late mortality has been studied in 308 severely burned adults. Two fluid regimens were compared simultaneously on an alternate-case basis. The results show (1) therapy with saline solutions alone was more effective than a fluid regimen deficient in electrolytes and (2) no additional advantage could be conclusively shown by combination of plasma with saline solutions. Furthermore, over a 14-year period there was only a 4% overall shock mortality in a total of 152 patients treated with saline solutions alone. There were no shock deaths in 127 patients with 10% to 50% surface-area burns. Late mortality, on the other hand, was not influenced by the early fluid therapy we employed.
Bocanegra M, Hinostroza F, Kefalides NA, Markley K, Rosenthal SM. A Long-Term Study of Early Fluid Therapy in Severely Burned AdultsIII. Simultaneous Comparison of Saline Solution Alone or Combined With Plasma. JAMA. 1966;195(4):268–274. doi:10.1001/jama.1966.03100040074020
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