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February 7, 1966

Continued Antibiotic Use in Pregnancy Supported

JAMA. 1966;195(6):41. doi:10.1001/jama.1966.03100060017007

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A high rate of recurrence of bacteriuria indicates antibiotic treatment for pyelonephritis in pregnant women possibly should be continued throughout pregnancy.

Preliminary indication of a high recurrence rate is seen by investigators at the University of California who are seeking to determine optimal treatment for such women patients.

L. D. Thrupp, MD, laboratory of infectious diseases, told The Journal that 35 of 88 patients followed for at least one month after initial drug treatment was stopped had recurrences.

The drugs being used in the study at Los Angeles County General Hospital are ampicillin, nitrofurantoin, chloramphenicol, and sulfisoxazole. Dr. Thrupp and Lester T. Hibbard, MD, Department of Obstetrics and Gynecology, have found in patients evaluated thus far, those initially treated with sulfisoxazole have had slightly more recurrences than those treated with the three other drugs, but the difference is not yet significant. Chloramphenicol was associated with the least number of recurrences.

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