In a previous study (see pp 445-452) the response of adult volunteers to type 4 adenovirus administered in an enteric-coated capsule was evaluated. Infection produced in this manner was limited to the lower intestinal tract and was not associated with any signs or symptoms of illness. Selective intestinal infection with type 4 virus produced moderate levels of neutralizing antibody. In addition, infection did not spread to susceptible contacts despite their prolonged exposure to individuals who shed virus from the intestinal tract. The virus preparation which was studied most extensively was grown in human diploid fibroblast culture (WI 38) and was found to be free of adventitious microbial agents and of oncogenic activity in suckling hamsters. The total experience from the laboratory studies and from the response of the volunteers to enteric infection suggested that administration of type 4 adenovirus in an entericcoated capsule might provide a safe and effective means
Edmondson WP, Purcell RH, Gundelfinger BF, Love JWP, Ludwig W, Chanock RM. Immunization by Selective Infection With Type 4 Adenovirus Grown in Human Diploid Tissue Culture: II. Specific Protective Effect Against Epidemic Disease. JAMA. 1966;195(6):453–459. doi:10.1001/jama.1966.03100060093026
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