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February 7, 1966


JAMA. 1966;195(6):482-483. doi:10.1001/jama.1966.03100060122034

Coagulation abnormalities develop in a variety of circumstances, and physicians practicing obstetrics, gynecology, urology, and pulmonary, cardiac and hepatic surgery are all aware of coagulation disorders which may imperil the patient's life. The appearance of clotting deviations is not surprising inasmuch as blood coagulation patterns are flexible, and affected by various tissues and organs which promote or deter clot formation. Any alteration in the coagulability of human blood must, therefore, be considered a phenomenon related to other processes.

Recent investigations described in the January and February issues of the Archives of Surgery demonstrate the importance of organ function in relation to coagulation, especially blood clotting in patients whose primary disease involves either the kidneys or liver and who subsequently receive renal or hepatic homografts.1,2 Significant clotting abnormalities were observed consistently before surgery. The initial homotransplant function tended to result in overcorrection and a postoperative phase of hypercoagulability. However, the

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