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March 14, 1966

Elevation of Plasminogen Linked to Atherogenesis?

JAMA. 1966;195(11):32. doi:10.1001/jama.1966.03100110024010

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A significant elevation in the concentration of plasminogen activator has been demonstrated in abdominal aorta tissue as compared with other sections of human aorta.

Since the incidence of atherosclerosis is much higher in the lower segment of the abdominal aorta than in the other sites tested, this finding may be of significance in atherogenesis, a group of investigators at Philadelphia General Hospital report.

An empirical correlation between atherosclerosis and fibrinolytic activity has been observed by others. The fibrinolytic activator from aortic adventitia of older subjects has been reported greater than that observed in young subjects.

Also, atheromatous sections of human aorta show greater fibrinolytic activity, and lower thromboplastic activity, than normal sections of aorta.

Since the incidence of atherosclerosis varies with different sections of the aorta, the Philadelphia group, headed by Etienne Van der Stichele, MD; Herschel Sandberg, MD, and Leonard J. Feinberg, PhD, decided it would be worthwhile to

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