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March 14, 1966

The Remote Effects of Cancer on the Nervous System

JAMA. 1966;195(11):975. doi:10.1001/jama.1966.03100110143061

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Although malignant neoplasms have been known and studied for as long as medical records exist, only for a comparatively short time has the association of such lesions with disorders of the neuromuscular system been recognized as frequent and important. The publications on the subject have been scattered through many journals, with the result that even yet the variety of involvement can be appreciated only with difficulty.

The present book brings together in one volume clear and detailed accounts of the clinical and pathologic features of all types so far recognized. Half the book is devoted to the possible mechanisms by which malignant tumors may produce effects at a distance, emphasis being placed on endocrinologic, nutritional, and immune responses. While this portion summarizes and even occasionally extends present knowledge, uncertainty still exists as to how malignant tumors produce degenerations of neural and muscular structures in the absence of metastasis to them.

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