A five-year study has been done on children sensitive to ragweed in which a comparison was made between specific hyposensitization injections and placebo injections. Even though the allergen injections may have had some beneficial effect on some children, the amount of benefit was indistinguishable from differences likely to occur in pure randomization experiments. No justification was found for promising any greater benefit to children treated with allergens than they would obtain from placebo injections.
Fontana VJ, Holt LE, Mainland D. Effectiveness of Hyposensitization Therapy in Ragweed Hay-Fever in Children. JAMA. 1966;195(12):985–992. doi:10.1001/jama.1966.03100120053013
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