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March 21, 1966

Comment: Predictability of Survival in the Individual Patient With Lung Cancer

JAMA. 1966;195(12):1036-1037. doi:10.1001/jama.1966.03100120104028

The main hope for survival rests in the patient who has a resectable tumor without overt evidence of regional or distant metastases. Cliffton classifies this type of malignancy as stage I and notes that the lesion is "probably resectable with a good chance for cure." In analyzing the figures, only one of five in this category manage to survive five years. This is still a poor result. Are there any specific prognostic factors that determine longterm survival even in this highly selected group?

The majority of reports indicate that there is no relationship between survival and age, sex, race, or duration of symptoms. Of pertinence is a recent report by Reinhoff et al (1965)14 who studied the pathological specimens of resected lungs. Factors which appeared significant to long-term survival were cell type and blood-vessel invasion. Bronchiolar carcinoma carries a much better prognosis (87% survival) than adenocarcinoma and well differentiated

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