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March 21, 1966

Osseous Metaplasia in Soft TissueDemonstration of Metastasis by 85Sr Scintiscanning

JAMA. 1966;195(12):1061-1064. doi:10.1001/jama.1966.03100120129043

RADIOISOTOPE scintiscanning for demonstration of osseous metastatic disease is now an accepted procedure. Abnormal scans can also be obtained in primary neoplasms of bone as well as in a number of benign conditions. Heterotopic ossification in the stroma of primary epithelial neoplasms is relatively uncommon.1 The presence of bone formation in soft-tissue metastatic disease is a rare occurrence, and the demonstration of this change by scintiscanning is consequently a singular event.

Heterotopic new bone in metastatic disease to the abdominal wall has been seen in three cases of intestinal adenocarcinoma1-3 and in one case of carcinoma of the bladder.4 Each of these instances may have represented surgical implantation of tumor cells rather than true hematogenous or lymphatic spread. However, heterotopic new bone was demonstrated both roentgenographically and histologically in a lymph node metastasis by Senturia et al5 in one case of adenocarcinoma of the rectum.


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