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March 28, 1966

Immunization Against Tumors 'Encouraging'

JAMA. 1966;195(13):29-31. doi:10.1001/jama.1966.03100130015004

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A new approach to cancer treatment—active immunization of the patient against his tumors—has produced "encouraging" results in preliminary clinical trials, investigators report.

These trials were conducted over the past three years in three Michigan hospitals. They involved injecting antigenic sera into the legs of 20 advanced cancer patients. Based on apparent effectiveness observed in ten of the patients, further studies with a larger series of patients will begin in the next few months.

According to a team of Wayne State University investigators and Detroit Institute of Cancer Research, the sera is prepared by coupling a suspension of cancer cells from the patient's tumor and an organic intermediate, bisdiazobenzidine, to a highly antigenic foreign protein, rabbit γ-globulin. This complex is then injected back into the tumor donor.

"We believe this autoimmune approach to therapy may hold more promise for early stage cancer patients, and perhaps, it may be most useful in

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