Serial hemodynamic and angiocardiographic studies demonstrated the spontaneous closure of an atrial septal defect in a 3-year-9-month-old white boy, the presence of which was confirmed in the second year of life. A possible myocarditis in the first year of life was considered to be potentially instrumental in the closure of this defect. Although similar observations have been made by others, to our knowledge this is the first such case, particularly at this age, reported in the literature.
Gerald C. Timmis, Seymour Gordon, Joseph O. Reed. Spontaneous Closure of an Atrial Septal Defect. JAMA. 1966;196(1):17–19. doi:10.1001/jama.1966.03100140071018