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April 11, 1966

The Rh-Sensitized Pregnant Woman

JAMA. 1966;196(2):171-172. doi:10.1001/jama.1966.03100150117029

Spectrophotometric analysis of amniotic fluid in Rhsensitized pregnant women has produced a dramatic change in the management of these patients while improving the outlook for the fetus.1 This test represents a significant addition to medical horizons because it offers a biochemical quantitation of fetal substances as the basis for venturing into intrauterine fetal therapy. This report represents a consolidation of two experiences in two separate centers and identifies diagnostic features which are the basis of current management.

Amniotic-Fluid Test.—  In a previous report the spectrophotometric analysis of amniotic fluid was described and the available information relating to the test was summarized.2 During the past year there have been many additional reports confirming the value of this procedure.1,3-6 One of the unfortunate developments in reporting the data is the lack of uniformity.1-3 We have tried to analyze the basis for the diverse kinds of data-reporting different from

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