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April 25, 1966

Renal Function in 29 Healthy Adults Before and After Nephrectomy

Author Affiliations

From the Renal Section, Veterans Administration Hospital (Dr. Ogden), and Division of Renal Diseases, Department of Medicine, University of Colorado Medical Center (Drs. Krohn and Holmes), Denver.

JAMA. 1966;196(4):322-324. doi:10.1001/jama.1966.03100170064019

Twenty-nine healthy subjects, who served as renaltransplant donors, were studied to determine the effect of nephrectomy on blood urea nitrogen (BUN), serum creatinine level, and renal clearance in the early postoperative period (1 to 18 days). A mean increase in BUN and creatinine of 26% and 33%, respectively, occurred. Clearance levels of endogenous creatinine and of paraaminohippurate were 70.5% and 70.2%, respectively, of the preoperative mean, indicating a rapid 40% increase in the function of the remaining kidney. No variation in renal function in relation to age of patient or postoperative day could be demonstrated in the early postoperative period.