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April 25, 1966

Bacterial Vaccine and Infectious Asthma

JAMA. 1966;196(4):371-372. doi:10.1001/jama.1966.03100170113044

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To the Editor:—  I feel your readers will be served by the following comments in reply to the recent letter (195:701, 1966) criticizing our article "Bacterial Vaccine and Infectious Asthma."All three points made by the writer concerning the definition of allergic illness, evaluation of patients' treatments, and the obtaining of nose and throat cultures were adequately discussed in our article (193:895, 1965). We suggest a more complete and careful review of our article by the writer for detailed answers to his critical remarks.The study was primarily designed to evaluate the effectiveness of a therapeutic agent, specifically hyposensitization with bacterial vaccine, and discuss the difficulties encountered by the investigators. The use of subjective symptomatology as a criteria for therapeutic effectiveness is undoubtedly influenced by a multitude of causative or precipitating factors in a disease such as asthma. However, no acceptable objective means are available today to test

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